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In clinical trials of Wegovy (FDA-approved semaglutide), participants achieved an average weight loss of approximately 15% over 68 weeks, with some participants achieving up to 20% with continued treatment and adherence, when combined with diet and exercise

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Additionally, arachidonic acid-15-lipoxygenase (ALOX15) knockdown or treatment with the lipoxygenase inhibitor baicalein has shown protective effects against ischemic brain damage in murine models (45)

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E., Asarian, L., Dahl, K., Lutz, T

Subsequently, we conducted validation at both the nucleic acid and protein levels, confirming a reduction in GLUT1 and GLUT6 expression (Fig